Applying the chemotherapy drug fluorouracil to skin might help improve the appearance of sun-damaged areas and reduce potentially precancerous patches, according to a small, new study.

    Fluorouracil is used to treat cancers of the colon, head and neck, pancreas and other organs. Changes in skin appearance have been noted in people undergoing treatment with systemic fluorouracil, and this led to the development of a skin cream that contains the cancer drug.

    The new study included 21 healthy volunteers with sun-damaged skin and actinic keratoses -- skin lesions that could develop into skin cancer -- on their faces. The participants applied 5 percent fluorouracil cream to their faces twice daily for two weeks.

    The researchers said that the number of actinic keratoses declined from an average of 11.6 lesions per person to an average of 1.5 lesions. There were also improvements in aging-related damage, including wrinkling and dark skin spots.

    The study, funded by Valeant Pharmaceuticals International, was published in the June issue of the journal Archives of Dermatology.

    "For patients in whom a course of topical fluorouracil is indicated for the treatment of actinic keratoses, there will likely be the additional benefit of a restorative effect from sun damage; this may provide further motivation for these patients to undergo the rigorous treatment," concluded Dr. Dana L. Sachs, of the University of Michigan Medical School, and colleagues.

    "It is possible that for some patients topical fluorouracil may have an important role against photo-aging," they wrote. "For others, however, it may not be cosmetically acceptable given that a standard course of therapy may last two to three weeks and the ensuring reaction can persist for several more weeks. Undoubtedly, there will be patients who desire a therapy such as topical fluorouracil for cosmetic purposes given the relatively low cost of this therapy compared with ablative laser resurfacing."

    一項(xiàng)最新的小規(guī)模研究發(fā)現(xiàn)，將化療藥物-氟尿嘧啶涂抹在被太陽(yáng)曬傷的區(qū)域有助于改善皮膚表面并可能降低癌癥前期的斑塊。

    氟尿嘧啶是用來(lái)治療結(jié)腸癌、頭頸癌、胰腺癌和其他器官等的癌癥。在對(duì)有關(guān)人群采用氟尿嘧啶進(jìn)行系統(tǒng)治療之后，其皮膚表面發(fā)生了明顯改觀，這也導(dǎo)致了含防癌藥物護(hù)膚霜的研制。

    該項(xiàng)研究是針對(duì)21位志愿者展開的，他們臉部的皮膚均被曬傷且患有光化性角化病-一種可演變?yōu)槠つw癌的皮膚損害。研究對(duì)象將氟尿嘧啶膏涂抹在臉上，一天兩次，堅(jiān)持兩周。

    研究人員指出光化性角化病數(shù)量從平均11.6塊損傷/人減少到平均1.5塊損傷/人；在對(duì)老齡化引起的身體損害如皺紋、暗斑等方面也有改善。

    由Valeant制藥國(guó)際資助的該項(xiàng)研究發(fā)表在《皮膚病學(xué)文獻(xiàn)》的6月刊物上。

    根據(jù)密西根大學(xué)醫(yī)學(xué)院的Dana L. Sachs博士和其他研究人員的總結(jié)得出，對(duì)于處在局部氟尿嘧啶治療過(guò)程中進(jìn)行光化性角化病的患者，除達(dá)到預(yù)期恢復(fù)效果外，還將可能獲得額外好處；這可能促使患者進(jìn)一步進(jìn)行更大程度的治療。

    他們寫道，對(duì)有些患者而言，局部氟尿嘧啶治療對(duì)預(yù)防光老化很可能起著重要作用；而對(duì)為追求美容的其他患者，這是不可取的，因?yàn)橐淮螛?biāo)準(zhǔn)的治療過(guò)程要持續(xù)2-3周，藥物反應(yīng)可能會(huì)持續(xù)更長(zhǎng)時(shí)間。但毫無(wú)疑問(wèn)，考慮到此類療法相對(duì)于激光剝皮較便宜，今后會(huì)有追求美容的病人采用諸如局部氟尿嘧啶治療的療法。